Italian Federation of Biological Societies

Federazione Italiana Società Biologiche

Uso di antimicrobici a fine vita: una revisione dell'ambito

 

Obiettivo: esaminare l’uso di antibiotici in pazienti che si avvicinano alla fine della vita, in termini di frequenza di prescrizione, scopo del trattamento, effetti benefici e avversi e contributo allo sviluppo della resistenza antimicrobica.

Progetto: revisione dell’ambito FONTI DEI DATI: Uno scienziato dell’informazione ha cercato Ovid MEDLINE, Ovid EMBASE, The Cochrane library, PubMed Clinical Queries, NHS Evidence, Epistemonikos, SIGN, NICE, Google Scholar dall’inizio fino a febbraio 2019 per qualsiasi progetto di studio incluso, ma non limitato a, studi clinici randomizzati, studi prospettici interventistici o osservazionali, studi retrospettivi e studi qualitativi. La ricerca di Ovid MEDLINE è stata aggiornata il 10 giugno 2020.
Selezione degli studi: studi che riportano l’uso di antibiotici in pazienti che si avvicinano alla fine della vita in qualsiasi ambiente e atteggiamenti e comportamenti dei medici in relazione alla prescrizione di antibiotici in questa popolazione

ESTRAZIONE DEI DATI: due revisori hanno selezionato studi per l’idoneità; due revisori hanno estratto i dati dagli studi inclusi. I dati sono stati analizzati per descrivere i modelli di prescrizione di antibiotici in diverse popolazioni di pazienti, i benefici e gli effetti avversi (per i singoli pazienti e la società in generale), il razionale per il processo decisionale e i comportamenti e gli atteggiamenti dei medici nei confronti del trattamento con antibiotici in questo gruppo di pazienti.

Risultati: sono stati inclusi ottantotto studi. La definizione di fine vita è molto variabile, così come l’uso di antibiotici nei pazienti che si avvicinano alla fine della vita. Le decisioni sulla prescrizione sono influenzate dall’età del paziente, dalla diagnosi primaria, dall’impostazione dell’assistenza e dagli obiettivi della terapia, sebbene le preferenze dei pazienti non siano sempre documentate o rispettate. Le infezioni delle vie urinarie e delle basse vie respiratorie sono le indicazioni più comunemente riportate con esiti in termini di controllo dei sintomi e sopravvivenza riportati in modo variabile. Un piccolo numero di studi ha riportato eventi avversi e resistenza agli antimicrobici. I medici a volte si sentono a disagio nel discutere il trattamento antibiotico alla fine della vita e trarrebbero beneficio dalle linee guida per l’assistenza diretta.

Conclusioni: l’uso di antibiotici nei pazienti che si avvicinano alla fine della vita è comune sebbene ci siano variazioni significative nella pratica. Ci sono una miriade di questioni biologiche, etiche, sociali, medico-legali e cliniche intrecciate associate all’argomento.

 

Malformazione venosa intraepatica gigante con coagulopatia intravascolare localizzata. Follow-up e trattamento durante la gravidanza

Le lesioni intraepatiche negli adulti, comunemente chiamate emangioma epatico, dovrebbero essere chiamate malformazioni venose intraepatiche (IHVM) o malformazioni venose intraepatiche giganti (GIHVM) quando più grandi di 10 cm secondo la classificazione ISSVA (gruppo di studio della società internazionale per le anomalie vascolari). I disturbi localizzati della coagulazione (LIC) nei pazienti con malformazioni venose sono abbastanza comunemente associati a malformazioni venose, provocano una diminuzione del fibrinogeno (<2g / l) e un aumento dei d-dimeri (> 1500 ng / ml) e potrebbero essere responsabili di trombosi intralesionale, episodi di dolore o sanguinamento Riportiamo un caso clinico di un paziente di 41 anni che ha presentato episodi di dolore dell’ipocondrio destro scoprendo un GIHVM sconosciuto all’ecografia con una storia precedente di episodi di sanguinamento uterino e aborti multipli.

una coagulazione intravascolare localizzata (LIC) associata con il GIHVM. Poiché il desiderio della paziente di rimanere incinta era importante, la nostra clinica multidisciplinare ha consentito una gravidanza con un attento monitoraggio clinico, biologico e di imaging e follow-up. L’inizio precoce dell’eparina a basso peso molecolare (EBPM) ha consentito con successo una gravidanza a termine e un parto senza complicazioni. È stata raggiunta la stabilità della lesione intraepatica e si è prevenuta la progressione da LIC a disturbo diffuso della coagulazione intravascolare (DIC).

Uso di antimicrobici a fine vita: una revisione dell'ambito
Uso di antimicrobici a fine vita: una revisione dell’ambito

Resilienza psicologica: un aggiornamento sulle definizioni, una valutazione critica e raccomandazioni di ricerca

Background: la capacità di resistere a esiti avversi o di dimostrare resilienza dopo l’esposizione a un trauma è un fiorente campo di studio. Eppure il dibattito in corso persiste riguardo alle definizioni di resilienza, generalizzabilità della letteratura esistente, correlati neurobiologici e un programma di ricerca di consenso. Obiettivi: per rispondere a queste pressanti domande, Drs. Christy Denckla e Karestan Koenen (co-presidenti) hanno convocato un pannello multidisciplinare che includeva i dottori. Dante Cicchetti, Laura Kubzansky, Soraya Seedat, Martin Teicher e David Williams all’incontro annuale 2019 della International Society for Traumatic Stress Studies (ISTSS). Le domande includevano (1) come si sono evolute le definizioni di resilienza, (2) quali sono i migliori approcci per catturare la complessità dei processi di resilienza e (3) quali sono le aree più importanti per la ricerca futura?

Thiol Oxidative Stress Assay
1021 Ethos Biosciences 1 kit 460.8 EUR
TBARS/Malondialdehyde Oxidative Stress Assay
1020 Ethos Biosciences 1 kit 373.2 EUR
Stress-induced-phosphoprotein 1 Antibody
20-abx110231 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress-Induced-Phosphoprotein 1 Antibody
20-abx115866 Abbexa
  • 878.40 EUR
  • 477.60 EUR
  • 150 ul
  • 50 ul
Stress-Induced-Phosphoprotein 1 Protein
20-abx262868 Abbexa
  • 393.60 EUR
  • 7676.40 EUR
  • 276.00 EUR
  • 10 ug
  • 1 mg
  • 2 µg
Mouse Oxidative Stress Primer Library
MOSL-I Real Time Primers 1 set 657.6 EUR
Human Oxidative Stress Primer Library
HOSL-I Real Time Primers 1 set 540 EUR
Rat Oxidative Stress Primer Library
ROSL-I Real Time Primers 1 set 657.6 EUR
Glycine max Stress-induced protein SAM22
1-CSB-YP333215GGV Cusabio
  • 814.80 EUR
  • 402.00 EUR
  • 2606.40 EUR
  • 1261.20 EUR
  • 1730.40 EUR
  • 522.00 EUR
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Human Stress-induced-phosphoprotein 1 (STIP1)
1-CSB-EP022831HU Cusabio
  • 456.00 EUR
  • 256.80 EUR
  • 1570.80 EUR
  • 672.00 EUR
  • 1047.60 EUR
  • 314.40 EUR
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Recombinant Human Stress-Induced-Phosphoprotein 1
7-06538 CHI Scientific 2µg Ask for price
Recombinant Human Stress-Induced-Phosphoprotein 1
7-06539 CHI Scientific 10µg Ask for price
Recombinant Human Stress-Induced-Phosphoprotein 1
7-06540 CHI Scientific 1mg Ask for price
Stress-induced-phosphoprotein 1 Polyclonal Antibody
42335-100ul SAB 100ul 399.6 EUR
Stress-induced-phosphoprotein 1 Antibody (HRP)
20-abx108777 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress-induced-phosphoprotein 1 Antibody (Biotin)
20-abx105941 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress-induced-phosphoprotein 1 Antibody (FITC)
20-abx107356 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress Induced Phosphoprotein 1 (STIP1) Antibody
20-abx174651 Abbexa
  • 1028.40 EUR
  • 526.80 EUR
  • 1 mg
  • 200 ug
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
20-abx142249 Abbexa
  • 444.00 EUR
  • 727.20 EUR
  • 376.80 EUR
  • 100 ul
  • 200 ul
  • 50 ul
Stress Induced Phosphoprotein 1 (STIP1) Antibody
20-abx129243 Abbexa
  • 510.00 EUR
  • 159.60 EUR
  • 1446.00 EUR
  • 693.60 EUR
  • 393.60 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Oxidative-Stress Responsive 1 (OXSR1) Antibody
20-abx114290 Abbexa
  • 878.40 EUR
  • 477.60 EUR
  • 150 ul
  • 50 ul
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
20-abx001131 Abbexa
  • 493.20 EUR
  • 710.40 EUR
  • 218.40 EUR
  • 376.80 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
abx031725-400ul Abbexa 400 ul 627.6 EUR
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
abx031725-80l Abbexa 80 µl 343.2 EUR
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
abx031726-400ul Abbexa 400 ul 627.6 EUR
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
abx031726-80l Abbexa 80 µl 343.2 EUR
Omi Stress-Regulated Endoprotease (OMI) Antibody
20-abx225224 Abbexa
  • 444.00 EUR
  • 727.20 EUR
  • 376.80 EUR
  • 100 ul
  • 200 ul
  • 50 ul
Stress Response Protein YvgO (yvgO) Antibody
20-abx300376 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Universal Stress Protein F (uspF) Antibody
20-abx300670 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress-Induced-Phosphoprotein 1 (STIP1) Antibody
abx238323-100ug Abbexa 100 ug 610.8 EUR
8-isoprostane oxidative stress ELISA Kit
8iso1 Detroit R&D 1 Kit 368.4 EUR
pER Stress Response-TA-luc Plasmid
PVTB00988-2a Lifescience Market 2 ug 427.2 EUR
Recombinant Stress Induced Phosphoprotein 1 (STIP1)
4-RPH120Hu01 Cloud-Clone
  • 599.54 EUR
  • 283.20 EUR
  • 1918.27 EUR
  • 719.42 EUR
  • 1318.85 EUR
  • 476.40 EUR
  • 4615.68 EUR
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Salmonella typhi Universal stress protein A (uspA)
1-CSB-MP820596SWW Cusabio
  • 382.80 EUR
  • 1297.20 EUR
  • 541.20 EUR
  • 961.20 EUR
  • 100ug
  • 1MG
  • 200ug
  • 500ug
Salmonella typhi Universal stress protein A (uspA)
1-CSB-EP820596SWW Cusabio
  • 733.20 EUR
  • 370.80 EUR
  • 2192.40 EUR
  • 1126.80 EUR
  • 1461.60 EUR
  • 476.40 EUR
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Salmonella typhi Universal stress protein A (uspA)
1-CSB-YP820596SWW Cusabio
  • 814.80 EUR
  • 402.00 EUR
  • 2606.40 EUR
  • 1261.20 EUR
  • 1730.40 EUR
  • 522.00 EUR
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Stress-induced-phosphoprotein 1 Polyclonal Conjugated Antibody
C42335 SAB 100ul 476.4 EUR
Escherichia coli Universal stress protein F (uspF)
1-CSB-EP339887ENV Cusabio
  • 733.20 EUR
  • 370.80 EUR
  • 2192.40 EUR
  • 1126.80 EUR
  • 1461.60 EUR
  • 476.40 EUR
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Escherichia coli Universal stress protein D (uspD)
1-CSB-EP364467ENV Cusabio
  • 733.20 EUR
  • 370.80 EUR
  • 2192.40 EUR
  • 1126.80 EUR
  • 1461.60 EUR
  • 476.40 EUR
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Human Stress Induced Phosphoprotein 1 (STIP1) Protein
20-abx168247 Abbexa
  • 844.80 EUR
  • 343.20 EUR
  • 2581.20 EUR
  • 994.80 EUR
  • 594.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Stress Response Protein YvgO (YVGO) Antibody (HRP)
20-abx300377 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress Response Protein YvgO (YVGO) Antibody (FITC)
20-abx300378 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Stress Response Protein YvgO (YVGO) Antibody (Biotin)
20-abx300379 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Universal Stress Protein F (USPF) Antibody (HRP)
20-abx300671 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Universal Stress Protein F (USPF) Antibody (FITC)
20-abx300672 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Universal Stress Protein F (USPF) Antibody (Biotin)
20-abx300673 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
Human Stress 70 protein, mitochondrial(HSPA9) ELISA kit
E01S0338-192T BlueGene 192 tests 1524 EUR
Human Stress 70 protein, mitochondrial(HSPA9) ELISA kit
E01S0338-48 BlueGene 1 plate of 48 wells 624 EUR
Human Stress 70 protein, mitochondrial(HSPA9) ELISA kit
E01S0338-96 BlueGene 1 plate of 96 wells 822 EUR
Rabbit Stress 70 protein, mitochondrial(HSPA9) ELISA kit
E04S0338-192T BlueGene 192 tests 1524 EUR

Metodi: Gli atti di questo panel sono riassunti in questo rapporto e temi importanti sono sintetizzati e integrati.

Risultati: sebbene siano emerse definizioni diverse, tutte condividevano un focus sulla concettualizzazione della resilienza a più livelli, dal livello biologico a quello strutturale sociale, un focus sulla natura dinamica della resilienza e un allontanamento dalla concettualizzazione della resilienza come solo un tratto individuale. Le aree critiche per la ricerca futura includevano 1) sforzi mirati per migliorare la valutazione che ha validità internazionale e interculturale, 2) sviluppare progetti all’interno dello studio che impiegano strategie di fenotipizzazione più intense, 3) esaminare i risultati su più livelli e domini e 4) integrare concettualizzazioni di resilienza dal livello individuale al contesto sociale più ampio a livello di salute della popolazione.

N-Ras Activation Assay

STA-400-N 20 assays
EUR 908.4
Description: Our Ras Activation Assays use visible agarose beads to selectively precipitate the active form of specific Ras protein of interest. The precipitated small GTPase is then detected by Western blot using a target-specific antibody included in the kit. Assays are available to detect specific isoforms H-Ras, K-Ras, and N-Ras, as well as a Pan-Ras assay that detects all three isoforms.

H-Ras Activation Assay Kit, Trial Size

STA-400-H-T 5 assays
EUR 483.6
Description: Our Ras Activation Assays use visible agarose beads to selectively precipitate the active form of specific Ras protein of interest. The precipitated small GTPase is then detected by Western blot using a target-specific antibody included in the kit. Assays are available to detect specific isoforms H-Ras, K-Ras, and N-Ras, as well as a Pan-Ras assay that detects all three isoforms.

K-Ras Activation Assay Kit, Trial Size

STA-400-K-T 5 assays
EUR 483.6
Description: Our Ras Activation Assays use visible agarose beads to selectively precipitate the active form of specific Ras protein of interest. The precipitated small GTPase is then detected by Western blot using a target-specific antibody included in the kit. Assays are available to detect specific isoforms H-Ras, K-Ras, and N-Ras, as well as a Pan-Ras assay that detects all three isoforms.

N-Ras Activation Assay Kit, Trial Size

STA-400-N-T 5 assays
EUR 483.6
Description: Our Ras Activation Assays use visible agarose beads to selectively precipitate the active form of specific Ras protein of interest. The precipitated small GTPase is then detected by Western blot using a target-specific antibody included in the kit. Assays are available to detect specific isoforms H-Ras, K-Ras, and N-Ras, as well as a Pan-Ras assay that detects all three isoforms.

Rac1 Activation Assay

STA-401-1 20 assays
EUR 908.4
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Rac2 Activation Assay

STA-401-2 20 assays
EUR 908.4
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Cdc42 Activation Assay

STA-402 20 assays
EUR 908.4
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay

STA-403-A 20 assays
EUR 908.4
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay

STA-403-B 20 assays
EUR 908.4
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay

STA-403-C 20 assays
EUR 908.4
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Arf1 Activation Assay

STA-407-1 20 assays
EUR 908.4
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay

STA-407-6 20 assays
EUR 908.4
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay

STA-408 20 assays
EUR 908.4
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay

STA-409 20 assays
EUR 908.4
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

Pan-RAS-IN-1

HY-101295 25mg
EUR 2043.6

Rap1 Activation Assay Kit

STA-406-1 20 assays
EUR 908.4
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit

STA-406-2 20 assays
EUR 908.4
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rac1 Activation Assay Kit, Trial Size

STA-401-1-T 5 assays
EUR 483.6
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Rac2 Activation Assay Kit, Trial Size

STA-401-2-T 5 assays
EUR 483.6
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Cdc42 Activation Assay Kit, Trial Size

STA-402-T 5 assays
EUR 483.6
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay Kit, Trial Size

STA-403-A-T 5 assays
EUR 483.6
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay Kit, Trial Size

STA-403-B-T 5 assays
EUR 483.6
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay Kit, Trial Size

STA-403-C-T 5 assays
EUR 483.6
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Rac1/Cdc42 Activation Assay Combo Kit

STA-404 2 x 20 assays
EUR 1305.6
Description: Our Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

Rap1 Activation Assay Kit, Trial Size

STA-406-1-T 5 assays
EUR 483.6
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit, Trial Size

STA-406-2-T 5 assays
EUR 483.6
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Arf1 Activation Assay Kit, Trial Size

STA-407-1-T 5 assays
EUR 483.6
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay Kit, Trial Size

STA-407-6-T 5 assays
EUR 483.6
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay Kit, Trial Size

STA-408-T 5 assays
EUR 483.6
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay Kit, Trial Size

STA-409-T 5 assays
EUR 483.6
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

96-Well Ras Activation ELISA Kit (Colorimetric)

STA-440 96 assays
EUR 1082.4
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

96-Well Ras Activation ELISA Kit (Chemiluminescent)

STA-441 96 assays
EUR 1082.4
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

RhoA/Rac1/CDC42 Activation Assay Combo Kit

STA-405 3 x 10 assays
EUR 1305.6
Description: Our RhoA/Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

Pan-PAX (Pan-PAX) Antibody

abx236136-100ug 100 ug
EUR 577.2

Rabbit Anti-Goat IgG, Antisera (Bulk)

60319-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Llama IgG (H+L chain), Antisera (Bulk)

30818-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Mouse IgG, Antisera (Bulk)

44319-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Human IgG, Antisera (Bulk)

10119-RAS-BLK 1-10L, bulk Ask for price

Ras Antibody

48578-100ul 100ul
EUR 399.6

Ras Antibody

48578-50ul 50ul
EUR 286.8

Ras Antibody

48602-100ul 100ul
EUR 399.6

Ras Antibody

48602-50ul 50ul
EUR 286.8

Ras Antibody

49408-100ul 100ul
EUR 399.6

Ras Antibody

49408-50ul 50ul
EUR 286.8

RAS Antibody

31153-100ul 100ul
EUR 302.4

RAS Antibody

31153-50ul 50ul
EUR 224.4

RAS antibody

10R-1779 100 ul
EUR 418.8
Description: Mouse monoclonal RAS antibody

Cytokeratin, pan (Epithelial Marker); Clone PAN-CK (Concentrate)

RA0430-C.5 0.5 ml
EUR 360

Pan myristoylation Antibody

1-CSB-PA465729
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

pan Cadherin Antibody

DF2942 200ul
EUR 420

PKC-pan Antibody

AF6197 200ul
EUR 420

pan Actin Antibody

AF0115 200ul
EUR 420

Pan myristoylation Antibody

1-CSB-PA885152
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

SSX pan antibody

70R-50426 100 ul
EUR 292.8
Description: Purified Polyclonal SSX pan antibody

FOXO1 pan antibody

70R-37057 100 ug
EUR 392.4
Description: Rabbit Polyclonal FOXO1 pan antibody

PKC pan antibody

70R-33408 100 ug
EUR 392.4
Description: Rabbit polyclonal PKC pan antibody

NBPF pan antibody

70R-51031 100 ul
EUR 292.8
Description: Purified Polyclonal NBPF pan antibody

Synuclein pan antibody

70R-30766 100 ug
EUR 392.4
Description: Rabbit polyclonal Synuclein pan antibody

Actin pan antibody

70R-31095 100 ug
EUR 392.4
Description: Rabbit polyclonal Actin pan antibody

Pan-Cadherin Antibody

48907-100ul 100ul
EUR 399.6

Pan-Cadherin Antibody

48907-50ul 50ul
EUR 286.8

pan Cadherin Antibody

45029-100ul 100ul
EUR 302.4

pan Cadherin Antibody

45029-50ul 50ul
EUR 224.4

pan Cadherin Antibody

45052-100ul 100ul
EUR 302.4

pan Cadherin Antibody

45052-50ul 50ul
EUR 224.4

pan CDH Antibody

37301-100ul 100ul
EUR 302.4

pan-AKT antibody

38602-100ul 100ul
EUR 302.4

pan-Cytokeratin antibody

23032-100ul 100ul
EUR 468

Synuclein-pan Antibody

33495-100ul 100ul
EUR 302.4

Synuclein-pan Antibody

33495-50ul 50ul
EUR 224.4

pan-AKT Antibody

36716-100ul 100ul
EUR 302.4

pan Endothelium antibody

10R-6386 100 ug
EUR 340.8
Description: Mouse monoclonal pan Endothelium antibody

pan Cadherin antibody

10R-7890 100 ug
EUR 386.4
Description: Mouse monoclonal pan Cadherin antibody

Keratin pan antibody

20R-2530 250 uL
EUR 612
Description: Rabbit polyclonal Keratin pan antibody

pan Cytokeratin antibody

10R-2060 100 ul
EUR 483.6
Description: Mouse monoclonal pan Cytokeratin antibody

Cytokeratin Pan antibody

10R-2096 100 ul
EUR 483.6
Description: Mouse monoclonal Cytokeratin Pan antibody

Actin-pan antibody

10R-A106a 100 ug
EUR 663.6
Description: Mouse monoclonal Actin-pan antibody

Actin-pan Antibody

33321-100ul 100ul
EUR 302.4

Actin-pan Antibody

33321-50ul 50ul
EUR 224.4

pan Keratin antibody

10R-2442 50 ug
EUR 486
Description: Mouse monoclonal pan Keratin antibody

LDH Pan antibody

10-1335 1 mg
EUR 310.8
Description: Mouse monoclonal LDH Pan antibody

LDH Pan antibody

10-1336 1 mg
EUR 310.8
Description: Mouse monoclonal LDH Pan antibody

pan Cadherin Antibody

20-abx149140
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Pan-AKT Antibody

20-abx125375
  • EUR 710.40
  • EUR 1028.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 50 ul

pan-AKT Antibody

20-abx002260
  • EUR 493.20
  • EUR 710.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Pan pLDH Antibody

abx023860-1mg 1 mg
EUR 410.4

Pan pLDH Antibody

abx023861-1mg 1 mg
EUR 410.4

Actin-pan Antibody

20-abx013019
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Synuclein-pan Antibody

20-abx013202
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

NBPF-pan Antibody

20-abx008107
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

SSX-pan Antibody

20-abx008681
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Pan SUMO Antibody

abx027085-400ul 400 ul
EUR 627.6

Pan SUMO Antibody

abx027085-80l 80 µl
EUR 343.2

Pan SUMO Antibody

abx027140-400ul 400 ul
EUR 627.6

Pan SUMO Antibody

abx027140-80l 80 µl
EUR 343.2

pan Cadherin Antibody

ABD2942 100 ug
EUR 525.6

pan Cadherin Antibody

ABD7514 100 ug
EUR 525.6

Actin- pan Antibody

ABF0115 100 ug
EUR 525.6

Actin- pan Antibody

ABF5288 100 ug
EUR 525.6

PKC- pan Antibody

ABF6197 100 ug
EUR 525.6

pan- AKT Antibody

ABD7208 100 ug
EUR 525.6

Pan Ubiquitin Antibody

abx415347-50ug 50 ug
EUR 678

pan ADH Antibody

abx433090-200ul 200 ul
EUR 460.8

SHANK (pan) Antibody

abx440129-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx440140-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx440246-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx442775-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx442938-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx442949-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx443055-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx443218-100ug 100 ug
EUR 678

SAPAP (pan) Antibody

abx443229-100ug 100 ug
EUR 678

Ankyrin (pan) Antibody

abx443335-100ug 100 ug
EUR 678

SHANK (pan) Antibody

abx443499-100ug 100 ug
EUR 678

SAPAP (pan) Antibody

abx443510-100ug 100 ug
EUR 678

Ankyrin (pan) Antibody

abx443616-100ug 100 ug
EUR 678

SHANK (pan) Antibody

abx443780-100ug 100 ug
EUR 710.4

SAPAP (pan) Antibody

abx443791-100ug 100 ug
EUR 710.4

Ankyrin (pan) Antibody

abx443897-100ug 100 ug
EUR 710.4

SHANK (pan) Antibody

abx444061-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx444072-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx444178-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx444342-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx444353-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx444459-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx444623-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx444634-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx444740-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx444980-100ug 100 ug
EUR 627.6

SAPAP (pan) Antibody

abx444991-100ug 100 ug
EUR 627.6

GRK (pan) Antibody

abx445060-100ug 100 ug
EUR 627.6

QKI (pan) Antibody

abx445076-100ug 100 ug
EUR 627.6

Ankyrin (pan) Antibody

abx445097-100ug 100 ug
EUR 627.6

Conclusione: quadri concettuali sempre più sofisticati e sfumati, insieme alla ricerca che fa leva sui progressi della genetica, della biologia molecolare, una maggiore capacità computazionale e set di dati più ampi e diversificati suggeriscono che il prossimo decennio di ricerca potrebbe portare a scoperte significative.

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